Serial serum creatine phosphokinase MB isoenzyme activity after myocardial infarction. Studies in the baboon and man.
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Serial serum creatine phosphokinase MB isoenzyme activity after myocardial infarction. Studies in the baboon and man.
Serum CPK-MB iosenzyme activity was measured serially after mercury embolization of the left circumflex coronary artery in five baboons and after clinical acute myocardial infarction (AMI) in 20 patients. The calculated amount of enzyme released into the baboons' circulation (CPK-MBR) correlated well (r = 0.991) with the amount of MB isoenzyme depleted from the myocardium (CPK-MBD) when a previ...
متن کاملCreatine kinase MB isoenzyme studies in diagnosis of myocardial infarction.
Serial measurements of the MB isoenzyme of creatine kinase, total creatine kinase, aspartate mainotransferase, and urea stable lactate dehydrogenase have been made in the serum of a series of 139 patients admitted with a diagnosis of suspected myocardial infarction. Serum MB isoenzyme measurements have also been made on postoperative surgical patients and patients with medical disorders known t...
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Since the initial report on the clinical value of serum glutamic oxalacetic transaminase (SGOT) determinations in the diagnosis of myocardial infarction (LaDue, Wroblewski, and Karmen, 1954), a considerable amount of work has been done on the blood levels of other enzymes liberated from necrosed heart cells. Because of lack of specificity and difficulty of estimation, very few other enzyme esti...
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The specificity of serum CPK-MB for acute myocardial infarction was examined by retrospective analysis of 401 consecutive patients admitted to a Coronary Care Unit over a three and one-half year period with suspected infarction in whom the isoenzyme was subsequently detected. Four patients (1% ) who died during the hospital admission had no autopsy evidence of acute myocardial infarction. All f...
متن کاملCreatine kinase isoenzyme MB in myocardial infarction: methods compared.
Several methods are available for specifically identifying and assessing the activity of MB isoenzyme of creatine kinase in serum. We compared two electrophoretic techniques with three column-chromatographic ones for efficacy in the diagnosis of myocardial infarction. No technique was considered absolute, but we found surprisingly large errors of diagnosis in the column-chromatographic techniqu...
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ژورنال
عنوان ژورنال: Circulation
سال: 1977
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.55.5.733